Power dissipation IC4
I cannot determine the load current for the TPS7A4901DGNT V-regulator (IC4) generating 12V->5V.
If too high it is a potentially critical component with a thermal resistance (junction-ambient) of 63.4°C/W for the chosen package. Would you have a conservative assessment for the power dissipation, if in fact a critical junction temperature is reached?
From the datasheet it looks like it could already be improved by using the DRB package. If there aren't any constraints, I'd suggest to do that in any case for derating reasons.