Is Vadj = 2.2V realistic?
The Vadj power supply is considered to be 2.2V across the design but is this feasible? Does the user application have a carrier that can provide 2.2V Vadj? The implications of 2.5V having to be used would be changes in net names, power estimations and possibly the addition of a series power resistor before the 1.8V LDO to share the dissipation. To be double-checked.